RW

About the PI 
Ruibing WANG, PhD, FRSC

Professor of Supramolecular Pharmaceutics and Biomaterials,
SKL of Mechanism and Quality of Chinese Medicine, Institute of Chinese Medical Sciences; Department of Pharmaceutical Sciences, Faculty of Health Sciences; MoE Frontiers Science Center for Precision Oncology

University of Macau
Avenida da Universidade, Taipa, Macau
E-mail: rwang@um.edu.mo
Phone: +853-8822-4689

Associate Editor, ACS Applied Bio Materials
E-mail: r.wang-office@abm.acs.org  

Associate Editor, Chinese Chemical Letters

 

Academic Qualifications

  • Ph.D. (2007) in Organic Chemistry, Queen’s University, Canada
    Advisor: Prof. Donal H. Macartney, Professor of Chemistry
  • B.Sc. (2002) in Chemistry (Gifted Class), Jilin University, China
    Advisor: Prof. Xi Zhang and Prof. Bai Yang, Professors of Chemistry and Materials Science

Working Experience

  • Aug 2023-Present, Professor of Supramolecular Pharmaceutics and Biomaterials, Institute of Chinese Medical Sciences, and Department of Pharmaceutical Sciences, Faculty of Health Sciences,
    University of Macau, Taipa, Macau SAR, China
  • Jan 2021-Sep 2024, Director of Global Affairs Office,
    University of Macau, Taipa, Macau SAR, China
  • Aug 2019-Aug 2023, Associate Professor of Supramolecular Pharmaceutics and Biomaterials, Institute of Chinese Medical Sciences, and Department of Pharmaceutical Sciences, Faculty of Health Sciences,
    University of Macau, Taipa, Macau SAR, China
  • Oct 2014-Aug 2019, Assistant Professor of Supramolecular Pharmaceutics and Biomaterials, Institute of Chinese Medical Sciences,
    University of Macau, Taipa, Macau SAR, China
  • Nov 2009-Oct 2014, Senior Scientist, BTG plc. (Canadian branch, formerly a part of Nordion Inc., now part of Boston Scientific), Ottawa, Canada
  • May 2008–Nov 2009, Associate Research Officer at Steacie Institute for Molecular Sciences,
    National Research Council of Canada, Ottawa, Canada
  • Aug 2007-May 2008, Postdoctoral Fellow, Department of Chemistry at Queen’s University, Canada

Awards and Honors
2024                 Macau Science and Technology Award (3rd Prize, Natural Science Award), Macau
2024                 Macau Science and Technology Award (3rd Prize, Technological Invention Award), Macau
2022                 Macau Science and Technology Award (2rd Prize, Natural Science Award), Macau
2022                 Silver Prize for the Guangdong-Hong Kong-Macao Greater Bay Area High-value Patent Portfolio Layout Competition
2022                 The First Prize for 2022 Bank of China Trophy One Million Dollar Macao Regional Entrepreneurship Competition
2021                 Faculty-Level Outstanding Academic Staff Award, University of Macau
2020                 Macau Science and Technology Award (3rd Prize, Technological Invention Award), Macau
2019                 2018-2019 Top 1% Reviewer in Cross-Fields by Publons
2019                 2018-2019 Top 1% Reviewer in Chemistry by Publons
2019                 Chinese Periodic Table of Young Chemist
2019                 UM Teaching Excellence Award (only 1 awardee each year at UM), Macau
2019                 China Macrocyclic Arenes and Supramolecular Chemistry Rising Star Award, China
2019                 Faculty-Level Best Teacher Award, Macau
2018                 Macau Science and Technology Award (3rd Prize, Natural Science Award), Macau
2018                 Faculty-Level Academic Award, Macau
2016                 CNRS Visiting Professorship, Marseille, France
2013                 BTG Business Excellerator Stage Award, Ottawa, Canada
2011                 Nordion Business Excellerator Sprinter Award, Ottawa, Canada
2008                 Outstanding Thesis Award at Queen’s, Kingston, Canada
2003-2007       Queen’s Graduate Awards, Kingston, Canada
2004-2007       Queen’s Conference Travel Awards, Kingston, Canada
2005-2006       Graduate Dean’s Doctoral Field Travel Grant at Queen’s, Kingston, Canada
2002                 Outstanding Graduate of Jilin University, Changchun, China
1998-2002       Excellent Undergraduate Scholarship, Jilin University, Changchun, China
1998-2002       Excellent Student Leadership, Jilin University, Changchun, China

Representative Publication

  1. Ruifeng Luo, Jinwei Liu, Linxin Dai, Tianshun Duan, Qingwen Zhang, Cheng Gao*, and Ruibing Wang*, “Stress-trained microalgae robots with probiotics backpack and intestinal brake for inflammatory bowel disease management”, Nature Communications, 2026, 17, 173.
  2. Mian Tang, Zhiqing Yang, Xingchen Tang, He Ma, Beibei Xie, Jiang-Fei Xu, Cheng Gao*, David Bardelang, Ruibing Wang*, “Hypoxia-initiated supramolecular free radicals induce intracellular polymerization for precision tumor therapy,” Journal of the American Chemical Society, 2025, 147, 3488-3499.
  3. Mian Tang, Junteng Qiu, Yunfeng Lu, Zhongke Liu, Yin Liu, Chenhui Luo, Chunhai Fan, Ruibing Wang*, “Molecular Recognition Driven Organelle Cross-Linking Induces Endoplasmic Reticulum Stress and Mitochondrial Dysfunction to Potentiate Cancer Immunotherapy,” Angewandte Chemie International Edition, 2025, 64, e202514530.
  4. Qun Guan, Le-Le Zhou, Zhiqing Yang, Beibei Xie, Yan-An Li, Ruibing Wang*, “An sp2 Carbon-Conjugated Covalent Organic Framework for Fusing Lipid Droplets and Engineered Macrophage Therapy,” Angewandte Chemie International Edition, 2025, 64, e202421416. VIP paper and Hot Paper!
  5. Hang Yin, Qian Cheng, Roselyne Rosas, Stephane Viel, Valerie Monnier, Laurence Charles, Didier Siri, Didier Gigmes, Mehdi Yemloul, Ruibing Wang*, Anthony Kermagoret*, David Bardelang*, “Molecular Stiffening by Macrocycle Clustering,” Angewandte Chemie International Edition, 2025, 64, e202420880. 
  6. Hongjie Zhang, Song Wang, Li Wang*, Shengke Li, Haowen Liu, Xinyi Zhu, Yuanxia Chen, Guoheng Xu, Mingming Zhang, Quanying Liu*, Ruibing Wang*, Kai Xiao,* “Bio-Inspired Retina by Regulating Ion-Confined Transport in Hydrogels,” Advanced Materials, 2025, 37, 2500809 . 
  7. Cheng Gao, Ruifeng Luo, Cheryl H.T. Kwong, Jinwei Liu, Mian Tang, Beibei Xie*, Tianshun Duan, Ruibing Wang*,  “Cancer vaccine from intracellularly gelated tumor cells functionalized with CD47 blockage and damage-associated molecular pattern exposure,” Cell Reports Medicine, 2025, 102092 . 
  8. Junyan Li, Ziyi Wang, Ruifeng Luo, Xingping Quan, Hong U Fong, Qian Cheng, Jianwen Wei, Leo Wang, Yonghua Zhao, Ruibing Wang*,, “Tumor Microenvironment Triggered In Situ Coagulation of Supramolecularly Engineered Platelets for Precise Tumor Embolization,” Advanced Science, 2025, 12, 2414879. 
  9. Ziyi Wang, Jianwen Wei, Ruibing Wang*, “Backpacked Neutrophils via Noncovalent Interactions: A Candidate for Nova Cell Therapy,” Matter, 2024, 7,  2800-2803.
  10. Cheng Gao, Qingfu Wang, Yuan-Fu Ding, Cheryl Kwong, Jinwei Liu, Beibei Xie, Jianwen Wei, Simon Lee, Greta Mok, and Ruibing Wang*, “Targeted therapies of inflammatory diseases with intracellularly gelated macrophages in mice and rats,” Nature Communications, 2024, 15, 328.
  11. Hang Yin, Roselyne Rosas, Stéphane Viel, Michel Giorgi, Valerie Monnier, Laurence Charles, Didier Siri, Didier Gigmes, Youssef Nassar, Floris Chevallier, Christophe Bucher*, Ruibing Wang*, Anthony Kermagoret*, David Bardelang*, “Internal Dynamics and Modular Peripheral Binding in Stimuli-Responsive 3:2 Host:Guest Complexes,” Angewandte Chemie International Edition, 2024, 63, e202315985.
  12. Ruifeng Luo, Jinwei Liu, Qian Cheng, Mitsuhiko Shionoya, Cheng Gao*, and Ruibing Wang*, “Oral microsphere formulation of M2 macrophage-mimetic Janus nanomotor for targeted therapy of ulcerative colitis,” Science Advances, 2024,10, eado6798.
  13. Mian Tang, Tianshun Duan, Yunfeng Lu, Jinwei Liu, Cheng Gao*, Ruibing Wang*, “Tyrosinase-Woven Melanin Nets for Melanoma Therapy through Targeted Mitochondrial Tethering and Enhanced Photothermal Treatment,” Advanced Materials, 2024, 36, 2411906.
  14. Cheng Gao, Cheryl H.T. Kwong, Mian Tang, Jinwei Liu, Hiotong Kam, Shengke Li, Simon M. Y. Lee, Chunhai Fan, Hua-Zhong Yu, Ruibing Wang*, “A bacterially engineered macrophage sponge as a neutralization decoy to treat bacterial infection,” Matter, 2023, 6, 3889-3911. Highlighted by Zhao et al, Matter, 2023, 6, 3695-3698.
  15. Ludan Yue, Cheng Gao, Junyan Li, Hanbin Chen, Simon M. Y. Lee, Ruifeng Luo, Ruibing Wang*, “Chemotaxis-guided self-propelled macrophage motor for targeted treatment of acute pneumonia,” Advanced Materials, 2023, 35, 202211626.
  16. Meng Xu, Haidong Zha, Jiamao Chen, Simon Ming-Yuen Lee, Qi Wang*, Ruibing Wang*, Ying Zheng*, ““Ice & Fire” Supramolecular Cell-Conjugation Drug Delivery Platform for Deep Tumor Ablation and Boosted Anti-Tumor Immunity,” Advanced Materials, 2023, DOI:10.1002/adma.202305287, in press. 
  17. Beibei Xie, Huichao Zhao, Yuanfu Ding, Ziyi Wang, Cheng Gao, Shengke Li,Kehan Zhang, Seong Wan Ip, Huazhong Yu, Ruibing Wang*, “Supramolecularly Engineered Conjugate of Bacteria and CellMembrane-Coated Magnetic Nanoparticles for EnhancedFerroptosis and Immunotherapy of Tumors,” Advanced Science, 2023, 10, 2304407. 
  18. Cheng Gao, Cheryl H.T. Kwong, Qingfu Wang, Hiotong Kam, Beibei Xie, Simon Ming-Yuen Lee, Guosong Chen, Ruibing Wang*, “Conjugation of macrophage-mimetic microalgae and liposome for antitumor sonodynamic immunotherapy via hypoxia alleviation and autophagy inhibition,” ACS Nano, 2023, 17, 4034-4049. 
  19. Xingping Quan, Xiao Liang,Yuanfu Ding, Yan Han, Junyan Li, Mengchen Yuan, Yiyang Li, Zhen Yuan, Ruibing Wang*, Yonghua Zhao* “Cryo-shocked platelet coupled with ROS-responsive nanomedicine for targeted treatment of thromboembolic disease,” ACS Nano, 2023, 17, 6519–6533.
  20. Cheng Gao, Qingfu Wang, Junyan Li, Cheryl H.T. Kwong, Jianwen Wei, Beibei Xie, Siyu Lu, Simon M. Y. Lee,* and Ruibing Wang*, “In vivo hitchhiking of immune cells by intracellular self-assembly of bacteria-mimetic nanomedicine for targeted therapy of melanoma,” Science Advances, 2022, 8, eabn1805 (Selected as Science Advances feature article, with artworks showcased online).
  21.  Ziyi Wang, Chen Sun, Kuikun Yang, Xiaoyuan Chen* and Ruibing Wang*, “Cucurbituril-Based Supramolecular Polymers for Biomedical Applications,” Angewandte Chemie International Edition, 2022, 61, e2022067.
  22. Kuikun Yang, Zhiqing Yang, Guocan Yu*, Zhihong Nie*, Ruibing Wang*, Xiaoyuan Chen*,“Polyprodrug Nanomedicines: An Emerging Paradigm for Cancer Therapy,” Advanced Materials, 2022, 34, 2107434.
  23. Kuikun Yang, Guocan Yu, Zhiqing Yang, Ludan Yue, Xiangjun Zhang, Chen Sun, Jianwen Wei, Lang Rao, Xiaoyuan Chen,* and Ruibing Wang,* “Supramolecular Polymerization-induced Nanoassemblies for Self-augmented Cascade Chemotherapy and Chemodynamic Therapy of Tumor,” Angewandte Chemie International Edition, 2021, 60, 17570-17578.
  24. Shuwen Guo, Qiaoxian Huang, Yuan Chen, Jianwen Wei, Jun Zheng, Leyong Wang, Yitao Wang and Ruibing Wang,* “Synthesis and Bioactivity of Guanidinium‐Functionalized Pillar[5]arene as a Biofilm Disruptor,” Angewandte Chemie International Edition, 2021, 60, 618-623 (hot paper and frontipiece highlight).
  25. Xue Yang, Qian Cheng, Valerie Monnier, Laurence Charles, Hakim Karoui, Olivier Ouari, Didier Gigmes, Ruibing Wang,* Anthony Kermagoret,* and David Bardelang,* “Guest exchange by a partial energy ratchet in water,” Angewandte Chemie International Edition, 2021, 60, 6617–6623.
  26. Hang Yin, David Bardelang* and Ruibing Wang,* “Macrocycles and Related  Hosts as supramolecular antidotes,” Trends in Chemistry, 2021, 3, 1-4.
  27. Ludan Yue, Kuikun Yang, Jianwen Wei, Mengze Xu, Chen Sun, Yuanfu Ding, Zhen Yuan, Shu Wang* and Ruibing Wang* “Supramolecular vesicles based on gold nanorods for precise control of gene therapy and deferred photothermal therapy,” CCS Chemistry, 2021, 3, 1860–1872.
  28. Ludan Yue, Kuikun Yang, Xin-Yue Lou, Ying-Wei Yang* and Ruibing Wang,* “Versatile roles of macrocycles in organic-inorganic hybrid materials for biomedical applications,” Matter, 2020, 3, 1557–1588.
  29. Chen Sun, Ziyi Wang, Ludan Yue, Qiaoxian Huang, Qian Cheng and Ruibing Wang,* “Supramolecular Induction of Mitochondrial Aggregation and Fusion,” Journal of the American Chemical Society, 2020, 142, 16523–16527 (featured as a Supplementary Cover Article).
  30. Xue Yang, Ruibing Wang,* Anthony Kermagoret,* and David Bardelang,* “Oligomeric Cucurbituril Complexes: from Peculiar Assemblies to Emerging Applications,” Angewandte Chemie International Edition, 2020, 132, 21464–21476.
  31. Cheng Gao, Qiaoxian Huang, Conghui Liu, Cheryl H.T Kwong, Ludan Yue, Jian-Bo Wan, Simon M. Y. Lee* and Ruibing Wang,* “Treatment of atherosclerosis by macrophage-biomimetic nanoparticles via targeted pharmacotherapy and sequestration of proinflammatory cytokines,” Nature Communications, 2020, 11, 2622. Highlighted by Nature Review Cardiology, 2020.
  32. Chenwen Li, Yang Zhao, Juan Cheng, Jiawei Guo, Qixiong Zhang, Xiangjun Zhang, Jiong Ren, Fengchao Wang, Jun Huang, Houyuan Hu, Ruibing Wang,* and Jianxiang Zhang,* “A Proresolving Peptide Nanotherapy for Site-Specific Treatment of Inflammatory Bowel Disease by Regulating Proinflammatory Microenvironment and Gut Microbiota,” Advanced Science, 2019, 6, 1900610.
  33. Sébastien Combes, Khoa Truong Tran, Mehmet Menaf Ayhan, Hakim Karoui, Antal Rockenbauer, Alain Tonetto, Valérie Monnier, Laurence Charles, Roselyne Rosas, Stéphane Viel, Didier Siri, Paul Tordo, Sylvain Clair, Ruibing Wang,* David Bardelang,* and Olivier Ouari,* “Triangular regulation of cucurbit[8]uril 1:1 complexes,” Journal of the American Chemical Society, 2019, 141, 5897-5907 (selected as a Supplementary Cover Article).
  34. Cheng Gao, Qiaoxian Huang, Qingping Lan, Yu Feng, Fan Tang, Maggie P.M. Hoi, Jianxiang Zhang, Simon M. Y. Lee,* and Ruibing Wang,* “A user-friendly herbicide derived from photo-responsive supramolecular vesicles,” Nature Communications, 2018, 9, 2967.
  35. Songling Han, Siyu Chen, Lanlan Li, Jin Li, Huijie An, Hui Tao, Yi Jia, Shan Lu, Ruibing Wang,* and Jianxiang Zhang,* “Multiscale and Multifunctional Emulsions by Host-Guest Interaction-Mediated Self-Assembly,” ACS Central Science, 2018, 4, 600. 

Community Services

University and Faculty Services

Director, Global Affairs office, University of Macau, Jan. 2021-Sep. 2024

Committee Member, UM Scholarship Committee, Nov. 2018-Jan 2022
Fellow, Chao Kuang Piu College, University of Macau, Oct. 2014-Present
Deputy Director, Editorial Office of Chinese Medicine, ISCM and University of Macau, Nov. 2016-Jan. 2021
Coordinator, Social and Academic Affairs, Academic Staff Association at University of Macau, March, 2016-2018

External Services

Associate Editor, ACS Applied Biomaterials, April 2025-Present

Associate Editor, Chinese Chemical Letters, Jan. 2025-Present

Editorial Advisory Board Member, ACS Applied Bio Materials, Jan. 2020-2025
Editorial Board Member, Chinese Chemical Letters, Aug. 2022-2025
Editorial Board Member, Supramolecular Materials (newly established journal jointly by Elsevier and Science Press), Jan. 2021-Present
Editorial Board Member, Chinese Journal of Chemical Education (Chinese Core journal), Jan 2017-Present
Examiner for National Natural Science Foundation of China (NSFC)
Examiner for French National Research Agency (ANR)
Examiner for Czech Science Foundation (GACR)
Examiner for Israel Science Foundation (ISF)
Examiner for US-Israel Binational Science Foundation (BSF)
Examiner for National Science Centre Poland (NCN)

Funding Agencies